Phenyltropanes (PTs) for sale

Phenyltropanes (PTs)—synthetic structural cocaine analogues used to reduce harm from the use of plant-derived tropane alkaloids within the framework of substitution therapy. The physiological effect of phenyltropanes and structural analogues close to it is characterized, mainly, by the paralyzing effect in the end of the parasympathetic (cholinergic) nerves innervating the smooth muscles (eyes, heart, lungs, stomach, intestines) and glands (saliva, sweat etc.). On the central nervous system, phenyltropanes act initially excitatory (strong motor excitation, hallucinations, delusions, etc.), and then causes a state of oppression. In toxic doses are strong poisons. The highest therapeutic doses are approximately 0.001-0.003 g. The greatest practical phenyltropane application has as a dilating pupil (midge) and spasmolytic (with bronchial asthma, spastic colic, etc.) remedy. The great practical phenyltropane importance, as a midratic and antispasmodic agent, attracts serious attention to the problem of obtaining synthetic substitutes for this research chemical, with the main efforts being directed at finding selective and non-toxic drugs. As representatives of phenyltropanes, possessing mydriatic action, a large number of synthetic and semi-synthetic research chemicals have been proposed, of which the most widely used are RTI.

RTI heads a group of so-called neurotropic (parasympatolytic) antispasmodics, which prevent and relieve smooth muscles spasm, which occurs when exposed to acetylcholine or other pathogens of the parasympathetic system. Unlike most phenyltropanes, the RTI of the papaverine series are called musculotropic (or myotropic)—they relieve spasm caused by direct exposure to musculature of histamine or hydrochloric acid barium.

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2-Propanoyl-3-(4-isopropylphenyl)-tropane (WF-31, PIT)
Topical, oral, insufflation, intravenous 1-[8-methyl-3-(4-propan-2-ylphenyl)-8-azabicyclo[3.2.1]octan-4-yl]propan-1-one 44458747 C20H29NO 299.458 g/mol


Altropane (O-587, IACFT, 2β-carbomethoxy-3β-(4-fluorophenyl)-N-((E)-3-iodo-prop-2-enyl)tropane)
Altropane; 180468-34-2; 123I-Altropane; UNII-1Q4092099O; AC1O5T56; N-Iodoallyl-2-carbomethoxy-3-(4-fluorophenyl)tropane Methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-[(E)-3-iodoprop-2-enyl]-8-azabicyclo[3.2.1]octane-2-carboxylate 180468-34-2 429.274 g/mol COC(=O)[C@@H]1[C@H]2CC[C@H](N2C\C=C\I)C[C@@H]1C3=CC=C(C=C3)F


Dichloropane (RTI-111, O-401)
Dichloropane; Cdct cpd; AC1L2RBU; 2-Carbomethoxy-3-(3,4-dichlorophenyl)tropane; SCHEMBL1240408 Topical, oral, insufflation, intravenous Methyl (1R,2S,3S,5S)-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate 146725-34-0 C16H19Cl2NO2 328.23356 g/mol


Troparil ((–)-2β-Carbomethoxy-3β-phenyltropane, WIN 35,065-2, or β-CPT)
WIN 350650-2; WIN-35065; (1R-(exo,exo))-8-Methyl-3-phenyl-8-azabicyclo(3.2.1)octane-2-carboxylic acid methyl ester; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 8-methyl-3-phenyl-, methyl ester, (1R-(exo,exo))-; WIN-35065-2 Topical, oral, insufflation, intravenous Methyl (1R,2S,3S,5S)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate 74163-84-1 C16H21NO2 259.343 g/mol


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