Substituted piperazine derivatives for sale
Substituted piperazine derivatives are a class of designer drugs and research chemicals that exhibit psychoactive properties that affect central nervous system functions. The research chemicals of this series stimulate release and inhibit the reuptake of dopamine, serotonin and norepinephrine. Some of these act as d-amphetamine, a combination of other piperazine derivatives has an effect on the body similar with MDMA. For the first time, the abuse of substituted piperazines was noted in the US. At the beginning of the 21st century, piperazines were widely distributed in Europe as a substitute for MDMA.
By structure, the piperazine derivatives used in legal research chemicals market can be combined into two groups: benzyl and phenyl substituted. Piperazines that occur in the legal RC's market circulation, the first group includes benzylpiperazine (BZP), methylbenzylpiperazine (MBZP), dibenzylpiperazine (DBZP) and methylenedioxybenzylpiperazine (MDBZP), to the 2nd - 4-methoxyphenylpiperazine (MeOPP), meta-Chlorophenylpiperazine (mCPP) , 3-trifluoromethylphenylpiperazine (TFMPP) and 4-fluorophenylpiperazine (pFPP).
Some of these substituted piperazines act as precursors or intermediates in the pharmaceutically active compounds synthesis, including ciprofloxacin, quinolone antibiotics, and certain tranquilizers. A number of substitute piperazine derivatives are metabolites of some drugs.
Routes of administration and effects
Piperazines are usually taken orally in the tablets or capsules form. With prolonged use, there is often a desire to accelerate the effect of the drug, which is usually achieved through smoking, inhalation, less often injections. To mitigate side effects, piperazines are often taken with alcohol or other psychoactive drugs. In this regard, people taking substituted piperazines are more likely to use several psychoactive research chemicals at the same time, in most cases combining the reception of piperazines with alcohol, cannabis and synthetic cannabinoids. Some piperazine derivatives, for example MDBZP, are mild stimulants and do not cause euphoria and psychedelic effects. Attempts to increase the effect by increasing the dose cause dizziness, nausea, vomiting and convulsions, i.e. there are all the side effects caused by piperazines, but without any effects of strong stimulants. These derivatives are not widely used; others, such as BZP and TFMPP, have been widely used in many countries of the world mainly as legal substitutes for controlled drugs—MDMA and amphetamine. In the literature, numerous intoxication cases with compounds of this group are described. To reliably detect the facts about chemical compounds use in the piperazine group, data on their biotransformation in the human body and the physico-chemical properties of the major metabolites are necessary. Information on the piperazine derivatives metabolism in literature is scarce. In accessible databases there is practically no information about physico-chemical properties of their main metabolites, which are necessary for choosing the sample preparation methods and analysis, as well as for interpreting the results obtained.