Substituted phenidates for sale
Phenidates (also known as substituted phenidates) refer to research chemicals class that predominantly produce traditional stimulant effects when administered. A substituted phenidate may be defined as an ester of ritalinic acid and its analogues. Since already from 1960s it is known that substituted phenidates (also known as phenidates) have a paradoxical effect on behavioral disorders. So, foreign studies report that treatment with phenidates is successful in 70-90% of adolescents, and, above all, it manifests itself in the nuclear symptoms reduction, such as motor anxiety and impaired attention. Controversy surrounding the use of substituted phenidates and other stimulant drugs has arisen because of undesirable side effects, unpredictable long-term effects, and social and ethical considerations regarding their use (the possibility of abuse) and spread. Numerous authors warn occurrence of side effects (sleep disorders, appetite loss, headaches, aggravation or clinical manifestation of latent tick).
An increase in heart rate and blood pressure has been reliably established. In addition, note the short-term effect after taking methylphenidate from 30 minutes to 5 hours, as well as a sedative effect. It is indicated that serum concentration is not very informative, since the ratio between the serum concentration of the stimulant and the clinical effect is not constant. They note the possibility of psychotic phenomena in chronic use, drug dependence and withdrawal symptoms. At the same time, as a remedy, atomoxetine is proposed as a sympatomimetic of the central action, a highly selective presynaptic carriers inhibitor of norepinephrine with numerous indications of side effects (abdominal pain, decreased appetite and body weight, sinus tachycardia, increased blood pressure, orthostatic hypotension, syncope, fatigue , weakness, drowsiness, irritability, mood swings, early awakenings, irritability). In the annotation to the drug, cases of psychotic and manic symptoms, anxiety, agitation, panic attacks, impulsiveness, akathisia are also indicated. In neurological practice, substituted phenidates are used to treat children with ADHD, for example, gliatilin to activate the reticular formation structures of the brain. According to pharmacodynamic studies, gliatilin acts on neurotransmission, the neuronal membrane plasticity function of the receptors. In 2017, a study published in Australia, based on 20-year follow-up data, on the inconclusive and ineffective ADHD phenidates treatment. Traditionally, with pronounced hyperactivity with aggressiveness, neuroleptics (chlorpromazine, thioridazine) are used with an aggravation indication of attention dysfunction, which limits their use and does not contribute to social adaptation. A few clinical trials and the empirical results of phenidates use do not yet allow expanding the experience of their use in ADHD (in addition, frequent ECG registration is required). In the research materials, the effectiveness of phenidates, benzodiazepines, anticonvulsant normotimic agents (phenytoin, carbamazepine, and capillary acid) is questionable, and the disease is exacerbated by barbiturates use.
Thus, in spite of the large number studies of different aspects of ADHD, including psychopharmacological approaches to the correction of this syndrome, the somatic-psychophysiological component remains undeveloped, and hence a targeted search for optimal medication. The expected positive effect of substituted phenidates pharmacotherapy is relevant in the aspects of improving the ability to concentrate, reduce impulsiveness and reduction.