Stimulants for sale
Stimulants (also referred to as psychostimulants) are psychotropic substances that activate mental and, to a lesser extent, physical activity of the organism. They stimulate higher mental functions, accelerate the process of thinking, quickly relieve fatigue, drowsiness and lethargy, increase motivation and efficiency, increase sociability, improve mood, improve the ability to perceive external stimuli (accelerate responses, sharpen hearing and vision, the ability to color), increase motor activity and muscle tone, improve coordination of movements, increase stamina and a little physical strength. Many of the research chemicals in this group are capable of causing narcotic addiction and addiction. The group of stimulants can include both drugs and commonly available drugs (tea, coffee, tobacco, Coca-Cola, Pepsi), as well as substances that are banned in many countries (cocaine, cathinone, methamphetamine, amphetamine, but amphetamines find limited use in medicine in Western countries). Preparations of other pharmacological groups, for example, some antidepressants, nootropics, adaptogens (for example, ginseng, pantocrine, eleutherococcus) and others, can also have psychostimulating effects.
Mechanism of action
Research chemicals stimulants release catecholamines from nerve endings and block their reverse neuronal capture by suppressing monoamine oxidase. The mechanism of action is associated with the indirect adrenomimetic stimulants action, because of which the excitatory processes in the brain are intensified. The stimulating effect of caffeine is based on inhibition of the activity of the enzyme phosphodiesterase, which destroys cAMP and cGMP, which leads to their accumulation in cells and causes adrenaline-like effects. The stimulating effect of methamphetamine and phenethylamine is associated with the norepinephrine release from the presynaptic endings vesicles and the noradrenergic system activation.
In psychiatry, stimulants are most often used for the therapy of attention deficit hyperactivity disorder. In addition, they are effective for a motivation and narcolepsy. In adynamic depression, most commonly found in schizophrenia, stimulants can be combined with antidepressants. Also indications for use are apato-abulic, stuporous and sub-stuporic conditions; neurotic disorders with retardation; asthenic conditions, accompanied by lethargy, apathy, drowsiness. Research chemicals stimulants can be used to increase the mood and interest in life in severe somatic patients with apathy and social isolation. Stimulants RC's can also be used to reduce the need for the use of narcotic analgesics in cancer patients in the terminal stage. They also counteract the excessive sedative effect of analgesics. Phenethylamines is used to eliminate drowsiness, increase mental and physical performance, as well as poisoning with drugs that depress the central nervous system and hypotension. Stimulants are used to relieve the symptoms of daytime sleepiness and episodes of falling asleep during narcolepsy. They are not effective against catalepsy. Sometimes research chemicals stimulants are used off-label for the clinical depression treatment and bipolar affective disorder, in particular, for the atypical depression treatment and resistant depression.
List of commonly used research chemicals stimulants
- Ephedrine and pseudoephedrine
Stimulants can cause mental dependence, insomnia, anorexia, irritability, sometimes tachycardia and increased blood pressure. With chronic abuse, the occurrence of stimulant psychosis is possible. In mentally ill, psychostimulants are capable of provoking an exacerbation of psychotic symptoms. In particular, amphetamine can cause an exacerbation of positive symptoms in patients with schizophrenia. Also, stimulants tend to cause a worsening of the course of Tourette's syndrome.